rg 108 Search Results


rg 108  (MuseChem Chemicals)
N/A
RG108 (CAS 48208-26-0) is a small molecule inhibitor of DNA methyltransferases (DNMTs). It functions by blocking the catalytic activity of DNMTs, specifically targeting DNMT1. RG108 is known as a DNA hypomethylating agent and has been
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rg-108  (Sino Biological)
N/A
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rg 108  (Santa Cruz Biotechnology)
92
Santa Cruz Biotechnology rg 108
Rg 108, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rg+108/RG+108/pmc05646965-57-36-40
Average 92 stars, based on 1 article reviews
rg 108 - by Bioz Stars, 2026-10
92/100 stars
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rg108  (Tocris)
93
Tocris rg108
(A) Representative double-plotted mouse locomotor actograms under different lighting conditions (LD 12:12 cycle, LD 16:8 cycle, constant darkness). Yellow and grey areas indicate light and dark phases, respectively. Black ticks indicate wheel-running behavior patterns. Red asterisks denote onset of <t>RG108</t> or vehicle infusion into the third ventricle of the brain. (B) Quantification of changes in the endogenous period in constant darkness in control (LD 12:12 cycle) and LD 16:8 (change from LD 12:12 to LD 16:8 cycle) conditions with RG108 or vehicle infusion. (Two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6-7, ns: not significant, *p < 0.05). (C) Quantification of the endogenous period at baseline (the first constant darkness) and at the after-effect period (the second constant darkness) following long photoperiod entrainment in the presence of RG108 or vehicle infusion. (RM two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6, ***p<0.001).
Rg108, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rg+108/RG+108/bio_rxiv__2022__06__30__498269-107-20-2
Average 93 stars, based on 1 article reviews
rg108 - by Bioz Stars, 2026-10
93/100 stars
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rg-108  (Federation of European Neuroscience Societies)
90
Federation of European Neuroscience Societies rg-108
(A) Representative double-plotted mouse locomotor actograms under different lighting conditions (LD 12:12 cycle, LD 16:8 cycle, constant darkness). Yellow and grey areas indicate light and dark phases, respectively. Black ticks indicate wheel-running behavior patterns. Red asterisks denote onset of <t>RG108</t> or vehicle infusion into the third ventricle of the brain. (B) Quantification of changes in the endogenous period in constant darkness in control (LD 12:12 cycle) and LD 16:8 (change from LD 12:12 to LD 16:8 cycle) conditions with RG108 or vehicle infusion. (Two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6-7, ns: not significant, *p < 0.05). (C) Quantification of the endogenous period at baseline (the first constant darkness) and at the after-effect period (the second constant darkness) following long photoperiod entrainment in the presence of RG108 or vehicle infusion. (RM two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6, ***p<0.001).
Rg 108, supplied by Federation of European Neuroscience Societies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rg+108/rg+108/pm25639476-163-11-19
Average 90 stars, based on 1 article reviews
rg-108 - by Bioz Stars, 2026-10
90/100 stars
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rg 108  (Cayman Chemical)
N/A
DNA methylation regulates gene expression in normal and malignant cells RG 108 is a non nucleoside DNA methyltransferase inhibitor IC 115 nM in vitro It significantly reduces the methylation of genomic DNA in cells at
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rg 108  (SignalChem)
N/A
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rg 108  (Biosynth Carbosynth)
N/A
Inhibitor of DNA methyltransferase 1. Inhibitor of DNA methyltransferase 1.
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Image Search Results


(A) Representative double-plotted mouse locomotor actograms under different lighting conditions (LD 12:12 cycle, LD 16:8 cycle, constant darkness). Yellow and grey areas indicate light and dark phases, respectively. Black ticks indicate wheel-running behavior patterns. Red asterisks denote onset of RG108 or vehicle infusion into the third ventricle of the brain. (B) Quantification of changes in the endogenous period in constant darkness in control (LD 12:12 cycle) and LD 16:8 (change from LD 12:12 to LD 16:8 cycle) conditions with RG108 or vehicle infusion. (Two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6-7, ns: not significant, *p < 0.05). (C) Quantification of the endogenous period at baseline (the first constant darkness) and at the after-effect period (the second constant darkness) following long photoperiod entrainment in the presence of RG108 or vehicle infusion. (RM two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6, ***p<0.001).

Journal: bioRxiv

Article Title: DNA methylation is a widespread mechanism of light-induced circadian clock period plasticity

doi: 10.1101/2022.06.30.498269

Figure Lengend Snippet: (A) Representative double-plotted mouse locomotor actograms under different lighting conditions (LD 12:12 cycle, LD 16:8 cycle, constant darkness). Yellow and grey areas indicate light and dark phases, respectively. Black ticks indicate wheel-running behavior patterns. Red asterisks denote onset of RG108 or vehicle infusion into the third ventricle of the brain. (B) Quantification of changes in the endogenous period in constant darkness in control (LD 12:12 cycle) and LD 16:8 (change from LD 12:12 to LD 16:8 cycle) conditions with RG108 or vehicle infusion. (Two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6-7, ns: not significant, *p < 0.05). (C) Quantification of the endogenous period at baseline (the first constant darkness) and at the after-effect period (the second constant darkness) following long photoperiod entrainment in the presence of RG108 or vehicle infusion. (RM two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n = 6, ***p<0.001).

Article Snippet: 1μM VIP (Tocris) dissolved in sterile water was applied at CT14 to the culture medium 15 mins prior to 200μM RG108 (dissolved in 0.66% DMSO) application in the medium.

Techniques: Control

(A) Representative wheel-running behavior actograms with brief light exposure (yellow bars) in constant darkness with a drug vehicle (left) or RG108 (right) injection (red asterisk) in the third ventricle. Bars above the actograms indicate the 12h light (yellow) and 12h dark (grey) cycle previously entrained to which mice were before release into constant darkness. Red and blue dashed lines indicate linear regression of locomotor activity onsets before and after light exposure, respectively. The slopes of regression lines are the calculated activity rhythm periods. Yellow arrows denote phase shifts. (B-C) Quantification of phase shifts (B) and period changes (C) following light exposure in vehicle- and RG108-injected mice. (Unpaired t-test, mean ± SEM, n = 5-7, ***p<0.001). (D) Quantification of the endogenous period before and after light exposure (baseline, after-effect) in vehicle- and RG108-injected mice. (RM two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n=5-7, ****p<0.0001).

Journal: bioRxiv

Article Title: DNA methylation is a widespread mechanism of light-induced circadian clock period plasticity

doi: 10.1101/2022.06.30.498269

Figure Lengend Snippet: (A) Representative wheel-running behavior actograms with brief light exposure (yellow bars) in constant darkness with a drug vehicle (left) or RG108 (right) injection (red asterisk) in the third ventricle. Bars above the actograms indicate the 12h light (yellow) and 12h dark (grey) cycle previously entrained to which mice were before release into constant darkness. Red and blue dashed lines indicate linear regression of locomotor activity onsets before and after light exposure, respectively. The slopes of regression lines are the calculated activity rhythm periods. Yellow arrows denote phase shifts. (B-C) Quantification of phase shifts (B) and period changes (C) following light exposure in vehicle- and RG108-injected mice. (Unpaired t-test, mean ± SEM, n = 5-7, ***p<0.001). (D) Quantification of the endogenous period before and after light exposure (baseline, after-effect) in vehicle- and RG108-injected mice. (RM two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n=5-7, ****p<0.0001).

Article Snippet: 1μM VIP (Tocris) dissolved in sterile water was applied at CT14 to the culture medium 15 mins prior to 200μM RG108 (dissolved in 0.66% DMSO) application in the medium.

Techniques: Injection, Activity Assay

(A) Representative double-plotted actograms of PER2::LUC bioluminescence rhythms in SCN slices treated with one of combinations of VIP, RG108, and their vehicles. Red and blue lines indicate linear regression of peaks before and after treatment (green triangles), respectively. Yellow arrows denote phase shifts. (B-C) Quantification of phase shifts (B) and period changes (C) following treatment. (Two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n=4-6, ns: not significant, **p<0.01).

Journal: bioRxiv

Article Title: DNA methylation is a widespread mechanism of light-induced circadian clock period plasticity

doi: 10.1101/2022.06.30.498269

Figure Lengend Snippet: (A) Representative double-plotted actograms of PER2::LUC bioluminescence rhythms in SCN slices treated with one of combinations of VIP, RG108, and their vehicles. Red and blue lines indicate linear regression of peaks before and after treatment (green triangles), respectively. Yellow arrows denote phase shifts. (B-C) Quantification of phase shifts (B) and period changes (C) following treatment. (Two-way ANOVA with Sidak’s multiple comparisons tests, mean ± SEM, n=4-6, ns: not significant, **p<0.01).

Article Snippet: 1μM VIP (Tocris) dissolved in sterile water was applied at CT14 to the culture medium 15 mins prior to 200μM RG108 (dissolved in 0.66% DMSO) application in the medium.

Techniques: